Steric Strain

Steric strain, a concept central to organic chemistry, denotes the unfavorable interactions that arise from the spatial proximity of bulky groups within a molecule. These groups, due to their size, can hinder molecular rotation or force atoms into strained conformations. Steric strain influences molecular stability, reactivity, and geometry, profoundly impacting chemical reactions' outcomes. By understanding steric effects, chemists can predict molecular behavior, design more efficient synthetic routes, and optimize reaction conditions. Steric strain considerations are vital in drug design, materials science, and organic synthesis, guiding researchers in developing novel compounds with desirable properties.

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