Steric Strain
Steric strain, a concept central to organic chemistry, denotes the unfavorable interactions that arise from the spatial proximity of bulky groups within a molecule. These groups, due to their size, can hinder molecular rotation or force atoms into strained conformations. Steric strain influences molecular stability, reactivity, and geometry, profoundly impacting chemical reactions' outcomes. By understanding steric effects, chemists can predict molecular behavior, design more efficient synthetic routes, and optimize reaction conditions. Steric strain considerations are vital in drug design, materials science, and organic synthesis, guiding researchers in developing novel compounds with desirable properties.
Questions
- Are steric strain, van der Waals strain, and van der Waals repulsion the same?
- How can I draw d -glucose in its chair conformation? Why it is the most common aldohexose in nature?
- What is the difference between steric and torsional strain?
- Why is steric strain most evident in cyclic molecules?
- Why is #C_6H_5CH_2CH_2Cl# less reactive than #H_3C-CH_2CH_2CH_2Cl#?
- What is steric strain in organic chemistry?
- Why is D-glucose the most common aldohexose in nature?
- One of the two chair structures of cis-1-chloro-3- methylcyclohexane is more stable than the other by 3.7 kcal/mol. Which is it?
- Why three hydroxyl groups cannot stay together with a carbon atom but it forms ketone? Is it because of steric?
- How many cyclic isomers does C5H10 have?
- Can a formula of #C_5H_10# generate geometric isomerism?
- How many monochlorinated products of methyl cyclohexane are optically active?
- Calculate the total number of cyclic isomeric carbonyl compounds of molecular formula C5H8O which can't show geometrical isomerism?
- Is the name 2-ethyl-1-iodocyclopentane correct for the following compound?