How does ORT help patients with Cholera?

Rice starches provide glucose as substrate for the carrier mediated co transport mechanism without increasing the luminal osmolality. Several studies have shown a reduction in fluid requirements when rice based rehydration solution is used instead of glucose based rehydration solution. In patients with cholera, a rice based ORT has been proven to be superior, in increasing fluid absorbtion of the intestines and reducing diarrhoea.

Cellular sodium - potassium ATPase extrudes sodium into the lateral cell spaces, creating an osmotic and electrochemical gradient that produces a net flow of water and solutes from the lumen into the blood stream. ORT uses this robust backup mechanism for intestinal absorption of salts and water in addition to the normal absorbtion, which is mediated by a sodium chloride-linked transport system at the brush border of the intestinal lumen into the cell.

When administered early, when symptoms first appear, ORT can significantly lower the number of deaths, especially during an epidemic. While it cannot stop the infectious process, it can correct dehydration, which can save lives.

Oral rehydration therapy (ORT) helps patients with cholera by replacing lost fluids and electrolytes caused by severe diarrhea and vomiting. This helps to prevent dehydration and electrolyte imbalances, which are common complications of cholera. ORT typically involves drinking a solution of water, salt, and sugar to replenish fluids and electrolytes lost during illness.