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What is the reaction of epoxide with grignard reagent?

Answer 1

The reaction of a Grignard with an epoxide results in a primary alcohol, with a chain length 2 carbons longer than the original chain.

#R-MgX + C_2H_4O rarr R-CH_2CH_2OMgX#

Clearly, the usual aqueous work-up will result in #RCH_2CH_2OH#, a primary alcohol that is 2 carbons longer than the original Grignard chain. Obviously this alcohol can be further elaborated to give for example an acid, an halide, or an olefin.

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Answer 2

Ella Allen

The reaction of an epoxide with a Grignard reagent typically involves the nucleophilic attack of the Grignard reagent on the electrophilic carbon of the epoxide ring. This results in the formation of a new carbon-carbon bond and the opening of the epoxide ring, yielding a tertiary alcohol as the final product.

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Answer from HIX Tutor

When evaluating a one-sided limit, you need to be careful when a quantity is approaching zero since its sign is different depending on which way it is approaching zero from. Let us look at some examples.