What is the difference between an electrophile and a nucleophile?
A nucleophile donates electrons to an electrophile.
All nucleophiles are Lewis bases, but not all Lewis bases are nucleophiles.
All electrophiles are Lewis acids, but not all Lewis acids are electrophiles.
NUCLEOPHILES VS. LEWIS BASES
The major difference between a nucleophile and a Lewis base is that:
- Nucleophilic behavior involves making a new bond, and is kinetic behavior.
- A Lewis base after having donated an electron pair, involved in Bronsted-basic activity, just wants a proton and is thermodynamic behavior.
Both want to donate electrons to accomplish their purposes.
ELECTROPHILES VS. LEWIS ACIDS
The major difference between an electrophile and a Lewis acid is that:
- Electrophilic behavior involves making a new bond, and is kinetic behavior.
- A Lewis acid after having accepted an electron pair, involved in Bronsted-acidic activity, just wants to give up a proton and is thermodynamic behavior.
Both want to accept electrons to accomplish their purposes.
In aqueous solution, we can look at the following example:
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Electrophiles accept electrons and are electron-deficient, seeking electron-rich sites. Nucleophiles donate electrons and are electron-rich, targeting electron-deficient sites.
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When evaluating a one-sided limit, you need to be careful when a quantity is approaching zero since its sign is different depending on which way it is approaching zero from. Let us look at some examples.
When evaluating a one-sided limit, you need to be careful when a quantity is approaching zero since its sign is different depending on which way it is approaching zero from. Let us look at some examples.
When evaluating a one-sided limit, you need to be careful when a quantity is approaching zero since its sign is different depending on which way it is approaching zero from. Let us look at some examples.
When evaluating a one-sided limit, you need to be careful when a quantity is approaching zero since its sign is different depending on which way it is approaching zero from. Let us look at some examples.
- How can I determine whether an E or an SN reaction will occur?
- Why in Nucleophilic addition-elimination reactions,does the #C=O# bond break when the nucleophile is added and not the#C-CL# bond ?
- Are nucleophiles Lewis bases? Why?
- Why is an sn2 reaction faster than an sn1 reaction?
- How are SN1 and SN2 reactions different?

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