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Does the action of atrial natriuretic peptide (ANP) on mesangial cells change glomerular filtration rate? Does increased release of renin?

Answer 1

Owen Allison

ANP increases glomerular filtration rate, but increased release of renin does not.

Effect of ANP

Atrial natriuretic peptide (ANP) relaxes the mesangial cells, which are located in the glomerulus of the nephron.

This increases pressure in the glomerular capillaries and thus increases the glomerular filtration rate (GFR).

Effect of renin

Renin is produced in the JG cells of the juxtaglomerular apparatus (juxta = next to).

(adapted from www.slideshare.net)

Thus, both ANP and renin affect urine output, but by different mechanisms.

ANP increases GFR, increasing urine output.
Renin increases the water permeability of the DCT and the collecting duct, decreasing urine output.

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Answer 2

Aria Johnson

ANP dilates afferent arterioles, increasing glomerular filtration rate. It inhibits renin release, reducing renin levels.

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Answer from HIX Tutor

When evaluating a one-sided limit, you need to be careful when a quantity is approaching zero since its sign is different depending on which way it is approaching zero from. Let us look at some examples.