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Do nucleophiles add to carbonyl carbons?

Answer 1

Ruby Allen

Yes, the many of the reactions of carbonyl compounds involve nucleophilic attack at the carbonyl carbon.

The carbonyl carbon has a partial positive charge, so it is a perfect target for attack by a nucleophile.

Some reactions that involve the addition of a nucleophile to a carbonyl carbon are:

Reduction by LiAlH₄

Grignard Reaction

Formation of cyanohydrins

Hydrolysis of esters

Formation of esters from acid chlorides

Conversion of esters to amides

Here's a video about nucleophilic addition to carbonyl compounds.

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Answer 2

Jacob Anderson

Yes, nucleophiles can add to carbonyl carbons through a reaction known as nucleophilic addition. In this reaction, the nucleophile attacks the electrophilic carbon atom of the carbonyl group, forming a new bond and resulting in the addition of the nucleophile to the carbonyl carbon. This reaction is a fundamental process in organic chemistry and is widely observed in reactions involving carbonyl compounds such as aldehydes, ketones, and carboxylic acids.

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Answer from HIX Tutor

When evaluating a one-sided limit, you need to be careful when a quantity is approaching zero since its sign is different depending on which way it is approaching zero from. Let us look at some examples.