A mutation occurred in the middle of a DNA sequence from the coding strand as shown by the partial sequence below. Determine the molecular impact of this mutation and explain the possible effects resulting from this mutation. Please be specific on this?

Normal DNA sequence: -3’…TTC GTC GCT…5’

Mutated DNA sequence: -3’…TTC ATC GCT…5’

Question

Normal DNA sequence: -3’…TTC GTC GCT…5’

Mutated DNA sequence: -3’…TTC ATC GCT…5’

Julian Aguilar · Accepted Answer

Transcribing has no immediate impact.

However, when the mRNA is translated, translation will be terminated early as the anticodon of the #UAG# codon transcribed in the mutated mRNA corresponds to a release factor that separates the ribosomal subunits.

Obviously, this means that the protein will be dysfunctional because translation will not synthesize all of its ended amino acid sequences.

Isabella Anderson · Answer

undefined The specific mutation and its molecular impact cannot be determined without knowing the original sequence and the nature of the mutation (e.g., substitution, insertion, deletion). However, potential effects of mutations in a DNA sequence include changes in the amino acid sequence of the resulting protein (if the mutation is in a protein-coding region), alterations in protein function, disruption of regulatory sequences, and potential effects on gene expression or splicing. Additionally, mutations can lead to genetic disorders or diseases if they affect critical genes or regulatory elements.

A mutation occurred in the middle of a DNA sequence from the coding strand as shown by the partial sequence below. Determine the molecular impact of this mutation and explain the possible effects resulting from this mutation. Please be specific on this?

Normal DNA sequence: -3’…TTC GTC GCT…5’ Mutated DNA sequence: -3’…TTC ATC GCT…5’

Normal DNA sequence: -3’…TTC GTC GCT…5’

Mutated DNA sequence: -3’…TTC ATC GCT…5’