A gene has the base sequence CGT AT. What is an example of a frameshift mutation on this gene?

Let's start by understanding what a frameshift mutation is.

When nucleotides are added or removed from DNA, it alters the reading frame, or the grouping of codons. Since a codon is a set of three nucleotides that corresponds to a particular amino acid, changing the codon will alter the amino acid sequence, which will affect the translated protein's ability to function.

Because codons are read in groups of three, it is crucial to remember that frameshifts only happen when a nucleotide is inserted or deleted that is not a multiple of three. For example, an insertion of three or six would not result in a shift in the positions of all subsequent nucleotides.

Another possibility is that the altered code has an early stop codon (UGA, UAG, or UGA) that causes translation to end too soon, producing an unusually short polypeptide.

The sequence CGT AT can be subjected to an infinite number of frameshift mutations. For example, you could add or remove one nucleotide (A, C, T, or G) or two, four, or five nucleotides.

Here are a few instances!

I hope this is useful.

Inserting a nucleotide after the second base (CGTAT) causes a frameshift mutation.